Murphy was married to British screenwriter Simon Monjack. The couple lived in Los Angeles.
Reports said the LA fire department responded to a medical call at Murphy's home in West Hollywood at 0800 local time (1600 GMT). Two hours later, she was pronounced dead at hospital.
Britanny was best remembered for her roles in hit Clueless
Murphy once dated Ashton Kutcher, who co-starred with her in the 2003 romantic comedy, Just Married.
Kutcher tweeted Sunday morning about Murphy's death: "2day the world lost a little piece of sunshine."
"My deepest condolences go out 2 Brittany's family, her husband, & her amazing mother Sharon," his tweet said.
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